Arthropen Vet 250 Injection An aid in the treatment of non-infectious inflammatory joint disease in horses.

ACTIVE CONSTITUENTS

 

Pentosan Polysulfate Sodium 250mg/mL

 

PACK SIZE

 

12 x 6mL Vials per outer carton

50mL Single vial

 

DESCRIPTION

 

Arthropen Vet 250 Injection is a sterile solution formulated as an aid in the treatment of non-infectious inflammatory joint disease in horses.

 

PHARMACOLOGY

 

Pentosan polysulfate sodium (PPS) is a semi-synthetic polysaccharide with a linear xylan (pentosan) backbone. Xylan is a hemicellulose derived from plant origin by extraction from the cell walls of hardwoods. PPS possesses anti-inflammatory, anti-arthritic and chondroprotective activities.

The beneficial effects of pentosan polysulfate sodium in joint disease are due to the following actions:

a)    Anti-inflammatory activity.

b)    Inhibition of neutrophil migration into the joint.

c)    Stimulation of hyaluronic acid synthesis by synovial fibroblasts, resulting in increased volume and viscosity of synovial fluid.

d)    Stimulation of proteoglycan synthesis by chondrocytes.

e)    Fibrinolytic activity, resulting in improved circulation to subchondral bone and peri-articular structures.

 

CLINICAL APPLICATION

 

Arthropen Vet 250 Injection is indicated as an aid in the treatment of non-infectious, inflammatory joint disease in the horse. Clinical applications include the following conditions: osteoarthritis, osteochondritis dissecans (OCD), traumatic joint and peri-articular inflammation.

 

If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.

 

DIRECTIONS FOR USE

 

Contraindicated for use in horses with clotting defects, traumatic haemorrhage, infection, liver/kidney failure, or within 2 days of surgery.

 

Administer by intramuscular or intra-articular injection.

Following withdrawal of the first dose, use the remainder of the vial within 28 days or discard the unused portion.

 

PRECAUTIONS

 

Due to the anti-coagulant properties of PPS, bleeding from local blood vessels following intra-articular administration is more likely if PPS is left in contact with the tissue along the injection track. The following steps are recommended for intra-articular injection of Arthropen Vet 250 Injection:

 

(I) Prepare site as for surgery, avoiding iodine-based skin preparations. Use a neutral, soapless skin cleanser.

 

(II) A 20 gauge non-cutting needle is suitable for injection. Introduce

into the joint space with steady even pressure.

 

(III) Allow approximately 1 mL of synovial fluid to escape before attaching the syringe containing Arthropen Vet 250 Injection. Withdraw synovial fluid into the syringe if possible before injecting into the joint.

 

(IV) Draw back on the syringe once or twice to mix Arthropen Vet 250 Injection with synovial fluid.

 

(V) Apply a firm elastic bandage  around the joint for 3 to 4 hours after injection and keep the horse in a confined space during this time.

 

Careful technique, avoiding tissue damage, and firm post-injection bandaging will minimise the risk of intra-articular haemorrhage, which is the most common cause of acute inflammatory swelling following intra-articular injection.

 

DOSAGE AND ADMINISTRATION

 

Intra-articular - 1mL by aseptic intra-articular injection. Injections may be repeated once weekly for 3 to 4 injections. More than one joint may be treated at a time. The horse should be rested for 2 weeks after the final injection, followed by a further 2 weeks of graded walking exercise before returning to work.

 

Intramuscular - 3mg/kg bodyweight (6mL/500kg horse) by intramuscular injection on four occasions with an interval of 5-7 days between injections.

 

MEAT WITHHOLDING PERIOD

 

28 Days

 

MEAT WITHHOLDING PERIOD NEW ZEALAND ONLY

 

Nil

 

RACING/EVENT WITHHOLDING PERIOD

 

If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.

 

FIRST AID

 

If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131126 or in New Zealand 0800 764 766.

 

DISPOSAL

 

Dispose of empty container by wrapping with paper and putting in garbage. Discarded  needles/sharps should immediately be placed in a designated and appropriately labelled “sharps” container.

 

STORAGE

 

Store between 2 and 8°C (Refrigerate. Do not freeze). Protect from light. Store vials in an upright position. Following withdrawal of the first dose, use the remainder of the vial within 28 days or discard the unused portion.

 

REGISTRATION

 

APVMA Approval No. 63265/12x6mL/0709 (Australia)

ACVM A10081 (New Zealand)

SENASA No. 12-079 (Argentina)

 

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