Cattle-Mate Gonadorelin Injection For the treatment of cystic ovaries, prevention of delayed ovulation and improvement of postpartum fertility in cattle.

ACTIVE CONSTITUENTS

Gonadorelin (as acetate)          100 μg/mL

PACK SIZE

100mL & 20mL single vial

INDICATIONS

Clinical applications for Cattle-Mate Gonadorelin Injection in cattle are as follows:

Oestrus synchronisation
Oestrus synchronisation protocols involving the use of Prostaglandin F2 (PGF2 ) and Gonadotrophin Releasing Hormone (GnRH) have been subjected to extensive study in dairy herds around the world. GnRH/PGF2 protocols have measured favourably against standard prostaglandin programs in terms of reproductive parameters such as pregnancy rate and calving to contraception interval.

Treatment of cystic ovaries
Cystic ovaries are an important infertility problem in dairy cattle. Ovarian cysts may be single or multiple, and of follicular or luteal origin. Clinical signs of ovarian cysts include irregular oestrus cycles, anoestrus and nymphomania. Diagnosis of ovarian cysts is by rectal palpation of the structures on one or both ovaries.

Prevention of delayed ovulation
Delayed ovulation can result in reduced conception rates due to asynchrony between ova and sperm at the time of artificial insemination (AI). Administration of Cattle-Mate Injection stimulates an LH surge and consequently induces ovulation, thereby preventing the problem of delayed ovulation.

Improvement of postpartum fertility
Resumption of normal ovarian cyclical activity in the early postpartum period is essential to minimise the calving to conception interval, or ‘days open’. Treatment of cows with Cattle-Mate Injection during the first 40 days of the postpartum period may initiate a resumption of cyclicity in acyclic cows, and reduce the incidence of postpartum ovarian disorders.

PHARMACOLOGY

Gonadorelin is a synthetic decapeptide, identical to the endogenous Gonadotrophin Releasing Hormone (GnRH). GnRH is synthesised and secreted in a pulsatile manner by the hypothalamus and is transported via the hypothalamichypophyseal portal circulation to its site of action, the anterior pituitary.

Gonadorelin induces the synthesis and release of gonadotrophins from the anterior pituitary, such that LH and FSH are released from the pituitary shortly after gonadorelin administration. LH and FSH act on the ovary to stimulate maturation of ovarian follicles and ovulation.

Gonadorelin is rapidly absorbed from the site of the intramuscular injection. Following absorption, rapid distribution of Gonadorelin occurs with concentrations at the site of action as well as in the pineal gland, posterior pituitary, ovaries, liver and kidney, greater than concentrations in plasma. The plasma half-life of gonadorelin is approximately 20 minutes in cattle. Gonadorelin undergoes rapid metabolism by peptidase enzymes into smaller inactive peptides and amino acids.

DIRECTIONS FOR USE

Following withdrawal of the first dose, use the remainder of the vial within 28 days or discard the unused portion.

Cattle: Injection to be given into the anterior half of the neck.

Cystic ovaries: 5 mL (500 μg Gonadorelin) by intramuscular injection.

Prevention of delayed ovulation: 2.5 mL (250 μg Gonadorelin) by intramuscular injection.

Improvement of postpartum fertility: 2.5 mL (250 μg Gonadorelin) by intramuscular injection.

Oestrus synchronisation: 1 mL (100 μg Gonadorelin) by intramuscular injection, for example:

Day 0....................1 mL Cattle-Mate Injection

Day 7.................... 2 mL Ovu-Late Injection (Cloprostenol as sodium salt 250 μg/mL)

Day 9....................1 mL Cattle-Mate Injection

Insemination........8-24 hours after second GnRH.

MEAT WITHHOLDING PERIOD

MEAT: NIL, MILK: NIL

TRADE ADVICE

EXPORT SLAUGHTER INTERVAL (ESI): This product does not have an ESI established. For advice on the ESI, contact the manufacturer on 02 9728 3505 before using this product.

FIRST AID

If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131126 or in New Zealand 0800 764 766.

DISPOSAL

Dispose of empty container by wrapping with paper and putting in garbage. Discarded needles/sharps should immediately be placed in a designated and appropriately labelled “sharps” container.

STORAGE

Store between 2 and 8°C (Refrigerate. Do not freeze). Protect from light.

REGISTRATION

APVMA Approval No. 81105/102328 (Australia)

ACVM No. A11104 (New Zealand)

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