Gastropell Forte contains omeprazole, a dose-dependant inhibitor of gastric acid secretion. Clinical trial data indicates that Gastropell Forte will inhibit gastric acid secretion to maintain gastric acidity at a non-aggressive level, which allows existing ulcers to heal within two weeks of commencing treatment, and that an ongoing daily dose will prevent the recurrence of ulcers.
30mL Single syringe
Omeprazole is an inhibitor of gastric acid secretion. When given on a daily basis, omeprazole inhibits the enzyme system regarded as the acid (proton) pump within the gastric mucosa of the stomach by binding to the enzyme and blocking the first step of acid production.
Even though it is dosed orally, Gastropell Forte does not act directly on the stomach fluid as it is ingested. The drug passes through the stomach to the small intestine, where it is absorbed and travels via the bloodstream to the acid secreting cells of the stomach.
The powerful antisecretory effect of Gastropell Forte causes a dramatic reduction in the acidity of stomach fluid within days of commencing treatment, and because the gastric fluid is no longer irritating to the stomach lining, ulcers then heal spontaneously within two weeks. Continuation with daily dosing then prevents ulcers from recurring.
The lower region of the stomach is permanently exposed to gastric acid and has a prostaglandin protective mechanism, which guards against acid attack. The squamous mucosa in the upper region of the stomach has, however, no inherent protection and frequent splashing with gastric acid fluid soon erodes the lining to cause spot lesions, which can develop into deep haemorrhaging ulcers within weeks.For the stabled performance horse given two or three feeds a day, the stomach is left for long periods without ingestion of feed and without the mat of ingesta on the surface of the stomach fluid that helps to contain the acidic fluid. This exposure to acid is then increased during intense exercise when the stomach volume is reduced to half that of the rested horse and the gastric acid is forced into the squamous region where it attacks the stomach lining. The stomach lining is in a continual process of erosion and repair depending on the acidity of the stomach fluid and the horse/s feeding and exercise pattern.The pattern of regular sessions of intense training and long periods of the day without ingestion of feed is, however, well tolerated by the performance horse in training if gastric acid secretion is blocked by Gastropell Forte – every day – and the gastric fluid is then not aggressive to the stomach lining.
DIRECTIONS FOR USE
PRECAUTIONS - If used in performance animals, regulations of relevant authorities regarding medication should be observed.
DOSAGE AND ADMINISTRATION
Give orally via syringe.
Discard unused portions within 3 days after completion of the treatment program.
Adult Horses -
10 mL/500 kg BW (2.0 mg/kg BW) once daily for two weeks followed by daily maintenance dosing.
Horses out of competition - 5mL/500 kg BW (1.0mg / kg BW)
Horses in Competition - 10 mL/500 kg BW (2.0 mg/kg BW) once daily while horses remain in training, as directed by a veterinarian.
Gastropell Forte 10 mL/500 kg BW can provide rapid healing of stomach ulcers while horses remain in training, which may be associated with the improvement in clinical signs within two weeks of commencing treatment.
When left untreated, ulcers can recur within two weeks with a severity and across an area equivalent to that prior to treatment. Available data indicates that regular daily maintenance dosing at a reduced rate prevents the recurrence of ulcers.
MEAT WITHHOLDING PERIOD
NOT TO BE USED in horses intended for human consumption.
RACING/EVENT WITHHOLDING PERIOD
If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.
May irritate the eyes and skin. Avoid contact with eyes and skin. Wash hands after use.
If poisoning occurs, contact a doctor or Poisons Information Centre.
Phone New Zealand 0800 764 766.
Dispose of empty syringe by wrapping with paper and placing in garbage.
Store below 30°C (Room temperature).
ACVM No. A10775 (New Zealand)
APVMA No. 82722