Pain Management

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance.
Engelhardt, G., Homma, D., Schlegel, K., Utzmann, R. and Schnitzler, C., 1995. Inflammation Research, 44(10), pp.423-433.

Comparison of efficacy and safety of paste formulations of firocoxib and Phenylbutazone in horses with naturally occurring osteoarthritis.
Doucet, M.Y., Bertone, A.L., Hendrickson, D., Hughes, F., MacAllister, C., McClure, S., Reinemeyer, C., Rossier, Y., Sifferman, R., Vrins, A.A. and White, G., 2008. Journal of the American Veterinary Medical Association, 232(1), pp.91-97.

Pharmacokinetics of meloxicam in animals and the relevance to humans.
Busch, U., Schmid, J., Heinzel, G., Schmaus, H., Baierl, J., Huber, C. and Roth, W., 1998. Drug metabolism and disposition, 26(6), pp.576-584.

Evaluation of Pharmacokinetic-Pharmacodynamic Relationships for Bio Release Meloxicam Formulations in Horses.
Burns, P.J., Morrow, C., Gilley, R.M. and Papich, M.G., 2010. Journal of Equine Veterinary Science, 30(10), pp.539-544.

Pharmacokinetics of intravenous and oral meloxicam in ruminant calves.
Coetzee, J.F., KuKanich, B., Mosher, R. and Allen, P.S., 2009. Vet Ther, 10(4), pp.E1-E8.

Development and validation of a dissolution test for meloxicam and pridinol mesylate from combined tablet formulation.
Vignaduzzo, S.E., Castellano, P.M. and Kaufman, T.S., 2010. Indian journal of pharmaceutical sciences,72(2), p.197.

Pharmacokinetics of meloxicam in plasma and urine of horses.
Toutain, P.L., Reymond, N., Laroute, V., Garcia, P., Popot, M.A., Bonnaire, Y., Hirsch, A. and Narbe, R., 2004. American journal of veterinary research, 65(11), pp. 1542-1547.

Pharmacokinetic-Pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint.
Toutain, P.L. and Cester, C.C., 2004. American journal of veterinary research, 65(11), pp.1533-1541.

Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys.
Sinclair, M.D., Mealey, K.L., Matthews, N.S., Peck, K.E., Taylor, T.S. and Bennett, B.S., 2006. American journal of veterinary research, 67(6), pp.1082-1085.

Meloxicam.
Noble, S. and Balfour, J.A., 1996. Drugs, 51(3), pp.424-30.

Physical Properties and Dissolution Behaviour of Meloxicam/Poloxamer Solid Dispersions Prepared By Hot Melt Method and Microwave Assisted Method.
Mukhija, U., Soni, N., Chawla, A. and Bhatt, D.C., 2012. International Journal of Research in Pharmacy & Science, 2(2).

Meloxicam - literature review.
Ellis Draaijer DVM

Pharmacokinetics of Ecofriendly Meloxicam in Healthy Dogs.
Mahmood, K.T., Ashraf, M., Mahmood, T. and Haq, I.U.,

Pharmacokinetics and pharmacodynamics of oral meloxicam tablets in healthy horses
Vander Werf, K., 2013.  (Doctoral dissertation, Kansas State University).

Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Affect Pain and Inflammation.
Steven G. Kammerling RPh, PhD. Louisiana State University

Extra label use of nonsteroidal anti-inflammatory drugs in cattle.
Smith, G.W., Davis, J.L., Tell, L.A., Webb, A.I. and Riviere, J.E., 2008. Journal of the American Veterinary Medical Association, 232(5), pp.697-701.

Comparative bioequivalence study of meloxicam drugs.
Karieva, E. and YUNUSOVA, K., 2011 Medical and Health Science Journal, 5, pp.112-115.

Evaluation of Pharmacokinetic-Pharmacodynamic Relationships for Bio Release Meloxicam Formulations in Horses.
Burns, P.J., Morrow, C., Gilley, R.M. and Papich, M.G., 2010. Journal of Equine Veterinary Science, 30(10), pp.539-544.

Pharmacokinetics of meloxicam in animals and the relevance to humans.
Busch, U., Schmid, J., Heinzel, G., Schmaus, H., Baierl, J., Huber, C. and Roth, W., 1998. Drug metabolism and disposition, 26(6), pp.576-584.

COX-1 and COX-2 inhibition in horse blood by Phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
Beretta, C., Garavaglia, G. and Cavalli, M., 2005. Pharmacological research, 52(4), pp.302-306.

Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum.
Little, D., Brown, S.A., Campbell, N.B., Moeser, A.J., Davis, J.L. and Blikslager, A.T., 2007. American journal of veterinary research, 68(6), pp.614-624.

Anti-inflammatory Drugs in Equine Neonatal Medicine. Part I: Nonsteroidal Anti-inflammatory Drugs.
Castagnetti, C. and Mariella, J., 2015. Journal of Equine Veterinary Science, 35(6), pp.475-480.

RheothRx (poloxamer 188) injection for the acute painful episode of sickle cell disease: a pilot study.
Adams-Graves, P., Kedar, A., Koshy, M., Steinberg, M., Veith, R., Ward, D., Crawford, R., Edwards, S., Bustrack, J. and Emanuele, M., 1997. Blood, 90(5), pp.2041-2046.

Effects of race distance on physical, hematological and biochemical parameters of endurance horses.
Adamu, L., Adzahan, N.M., Abdullah, R. and Ahmad, B., 2010. American Journal of Animal and Veterinary Sciences,5(4), pp.244-248.

Bioequivalence and bioequivalency testing.
Balthasar, J.P., 1999. American Journal of Pharmaceutical Education, 63(2), p.194.

Impact of transmammary-delivered meloxicam on biomarkers of pain and distress in piglets after castration and tail docking.
Bates, J.L., Karriker, L.A., Stock, M.L., Pertzborn, K.M., Baldwin, L.G., Wulf, L.W., Lee, C.J., Wang, C. and Coetzee, J.F., 2014. PloS one, 9(12), p.e113678.

The effect of steroidal and non-steroidal anti-inflammatory drugs on the cellular immunity of calves with experimentally-induced local lung inflammation.
Bednarek, D., Szuster-Ciesielska, A., Zdzisiñska, B., Kondracki, M., Paduch, R. and Kandefer-Szerszeñ, M., 1999. Veterinary immunology and immunopathology, 71(1), pp.1-15.

Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia.
Coetzee, J.F., Mosher, R.A., KuKanich, B., Gehring, R., Robert, B., Reinbold, J.B. and White, B.J., 2012. BMC veterinary research, 8(1), p.1.

A targeted lipidomics approach to the study of eicosanoid release in synovial joints.
de Grauw, J.C., van de Lest, C.H. and van Weeren, P.R., 2011. Arthritis research & therapy, 13(4), p.1.

One-month intravenous toxicity studies of poloxamer 188 in male Sprague-Dawley rats and in beagle dogs.
Duvinage, C., Millecamps, S., Sagnier, A., Guffroy, M., Sarsat, J.P. and Belin, V., 1996. Toxicology Letters, 88, p.101.

Safety of meloxicam: a global analysis of clinical trials.
Distel, M., Mueller, C., Bluhmki, E. and Fries, J., 1996. Rheumatology, 35(suppl 1), pp.68-77.

The effect of meloxicam on pain sensitivity, rumination time, and clinical signs in dairy cows with endotoxin-induced clinical mastitis.
Fitzpatrick, C.E., Chapinal, N., Petersson-Wolfe, C.S., DeVries, T.J., Kelton, D.F., Duffield, T.F. and Leslie, K.E., 2013. Journal of dairy science, 96(5), pp.2847-2856.

Investigation on the clinical efficacy and safety of meloxicam (Metacam) in the treatment of non-infectious locomotor disorders in pigs.
Friton, G.M., Philipp, H., Schneider, T. and Kleemann, R., 2002. Berliner und Munchener Tierarztliche Wochenschrift, 116(9-10), pp.421-426.

Clinical efficacy of meloxicam (Metacam) and flunixin (Finadyne) as adjuncts to antibacterial treatment of respiratory disease in fattening cattle.
Friton, G.M., Cajal, C., Ramirez, R.R. and Kleemann, R., 2003. Berliner und Munchener Tierarztliche Wochenschrift, 117(7-8), pp.304-309.

Long-term effects of meloxicam in the treatment of respiratory disease in fattening cattle.
Friton, G.M., Cajal, C. and Ramirez-Romero, R., 2005. Veterinary Record: Journal of the British Veterinary Association, 156(25).

Clinical and anti-inflammatory effects of treating endotoxin-challenged pigs with meloxicam.
Friton, G.M., Schmidt, H. and Schrödl, W., 2006. Veterinary Record: Journal of the British Veterinary Association, 159(17).

Effect of local anaesthesia and/or analgesia on pain responses induced by piglet castration.
Hansson, M., Lundeheim, N., Nyman, G. and Johansson, G., 2011. Acta Veterinaria Scandinavica, 53(1), p.1.

The impact of meloxicam on postsurgical stress associated with cautery dehorning.
Heinrich, A., Duffield, T.F., Lissemore, K.D., Squires, E.J. and Millman, S.T., 2009. Journal of Dairy Science, 92(2), pp.540-547.

The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic. Heinrich, A., Duffield, T.F., Lissemore, K.D. and Millman, S.T., 2010. Journal of Dairy Science, 93(6), pp.2450-2457.

Pharmacokinetics of meloxicam in adult goats: a comparative study of subcutaneous, oral and intravenous administration.
Karademir, U., Erdogan, H., Boyacioglu, M., Kum, C., Sekkin, S. and Bilgen, M., 2016. New Zealand veterinary journal, 64(3), pp.165-168.

Bioavailability and pharmacokinetics of oral meloxicam in llamas.
Kreuder, A.J., Coetzee, J.F., Wulf, L.W., Schleining, J.A., KuKanich, B., Layman, L.L. and Plummer, P.J., 2012. BMC veterinary research, 8(1), p.1.

Pharmacodynamics and pharmacokinetics of miloxicam in the horse.
Lees, P., Sedgwick, A.D., Higgins, A.J., Pugh, K.E. and Busch, U., 1991. British Veterinary Journal, 147(2), pp.97-108.

Comparative plasma pharmacokinetics of meloxicam in sheep and goats following intravenous administration.
Shukla, M., Singh, G., Sindhura, B.G., Telang, A.G., Rao, G.S. and Malik, J.K., 2007. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 145(4), pp.528-532.

Efficacy of a buccal meloxicam formulation for pain relief in Merino lambs undergoing knife castration and tail docking in a randomised field trial.
Small, A.H., Belson, S., Holm, M. and Colditz, I.G., 2014. Australian veterinary journal, 92(10), pp.381-388.

Relationships for BioRelease Meloxicam Formulations in Horses.
Burns, P.J., Morrow, C., Gilley, R.M. and Papich, M.G., 2010. Evaluation of Pharmacokinetic-Pharmacodynamic Journal of Equine Veterinary Science,30(10), pp.539-544.

Effects of local anesthetic and a nonsteroidal antiinflammatory drug on pain responses of dairy calves to hot-iron dehorning. Stewart, M., Stookey, J.M., Stafford, K.J., Tucker, C.B., Rogers, A.R., Dowling, S.K., Verkerk, G.A., Schaefer, A.L. and Webster, J.R., 2009. Journal of Dairy Science,92(4), pp.1512-1519.

Pharmacokinetics of intravenously and orally administered meloxicam in sheep.
Stock, M.L., Coetzee, J.F., KuKanich, B. and Smith, B.I., 2013. American journal of veterinary research, 74(5), pp.779-783.

Nonsteroidal anti-inflammatory drug therapy for neonatal calf diarrhea complex: Effects on calf performance.
Todd, C.G., Millman, S.T., McKnight, D.R., Duffield, T.F. and Leslie, K.E., 2010. Journal of animal science, 88(6), pp.2019-2028.

Break point of serum creatine kinase release after endurance exercise.
Totsuka, M., Nakaji, S., Suzuki, K., Sugawara, K. and Sato, K., 2002. Journal of Applied Physiology, 93(4), pp.1280-1286.

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance
Engelhardt, G., Homma, D., Schlegel, K., Utzmann, R. and Schnitzler, C., 1995.. Inflammation Research, 44(10), pp.423-433.

Palatability and pharmacokinetics of flunixin when administered to sheep through feed.
Marini, D., Pippia, J., Colditz, I.G., Hinch, G.N., Petherick, C.J. and Lee, C., 2016. PeerJ, 4, p.e1800.

Somatic cell count, probability of re-treatment, and culling of dairy cows with mild clinical mastitis.
McDougall, S., Bryan, M.A. and Tiddy, R.M., 2009. Journal of dairy science, 92(9), pp.4421-4431.

A validated HPLC method for the determination of meloxicam in pharmaceutical preparations.
Nemutlu, E., Sayin, F., Basci, N.E. and Kir, S., 2007. HACETTEPE UNIVERSITY JOURNAL OF FACULTY OF PHARMACY,27(2), p.107.

A pharmaceutical excipients with therapeutic behaviors.
Patel, H.R., Patel, R.P. and Patel, M.M., 2009. Poloxamers: International Journal of PharmTech Research, 1(2), pp.299-303.

Effects of meloxicam or tolfenamic acid administration on the pain and stress responses of Merino lambs to mulesing.
Paull, D.R., Lee, C., Atkinson, S.J. and Fisher, A.D., 2008. Australian veterinary journal, 86(8), pp.303-311.

Haematological response to different workload in jumper horses.
Piccione, G., Giannetto, C., Fazio, F., Di Mauro, S. and Caola, G., 2007. Bulg J Vet Med, 10(1), pp.21-28.

Poloxamer 188 facilitates the repair of alveolus resident cells in ventilator-injured lungs.
Plataki, M., Lee, Y.D., Rasmussen, D.L. and Hubmayr, R.D., 2011. American journal of respiratory and critical care medicine,184(8), pp.939-947.

Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor κB) activation: role of arachidonic acid.
Mitchell, J.A., Saunders, M., Barnes, P.J., Newton, R. and Belvisi, M.G., 1997Molecular pharmacology, 51(6), pp.907-912.

Vascular pathology in phenylbutazone intoxicated horses.
Meschter, C.L., Maylin, G.A. and Krook, L., 1984. The Cornell veterinarian, 74(3), pp.282-297.

Effects of large doses of phenylbutazone administration to horses.
MacKay, R.J., French, T.W., Nguyen, H.T. and Mayhew, I.G., 1983American journal of veterinary research, 44(5), pp.774-780.

Ultrasonographic renal changes associated with phenylbutazone administration in three foals.
Léveillé, R., Miyabayashi, T., Weisbrode, S.E., Biller, D.S., Takiguchi, M. and Williams, J.F., 1996. The Canadian Veterinary Journal, 37(4), p.235.

Renal papillary necrosis in horses after phenylbutazone and water deprivation.
Gunson, D.E. and Soma, L.R., 1983. Veterinary Pathology Online, 20(5), pp.603-610.

The hyperpnoea produced by intravenous administration of salicylates.
Cochran, J.B. and Ramsay, A.G., 1956. British journal of pharmacology and chemotherapy, 11(4), pp.364-366.

Pharmacokinetics and plasma concentrations of acetylsalicylic acid after intravenous, rectal, and intragastric administration to horses.
Broome, T.A., Brown, M.P., Gronwall, R.R., Casey, M.F. and Meritt, K.A., 2003. Canadian journal of veterinary research, 67(4), p.297.

Mechanism of action of acetaminophen: is there a cyclooxygenase 3?.
Botting, R.M., 2000. Clinical Infectious Diseases, 31(Supplement 5), pp.S202-S210.

Renal toxicity of non-steroidal anti-inflammatory drugs.
Black, H.E., 1986. Toxicologic pathology, 14(1), pp.83-90.

Inflammation and the mechanism of action of anti-inflammatory drugs.
Vane, J.O.H.N. and Botting, R., 1987. The FASEB journal, 1(2), pp.89-96.

The mechanism of action of anti-inflammatory drugs.
Vane, J.R., 2000. InAdvances in eicosanoid research (pp. 1-23). Springer Berlin Heidelberg.

Renal medullary rim sign in 2 adult quarter horses.
Ramirez, S., Seahorn, T.L. and Williams, J., 1998. The Canadian Veterinary Journal, 39(10), p.647.

The fight against rheumatism: from willow bark to COX-1 sparing drugs.
Vane, J.R., 2000. Journal of physiology and pharmacology, 51(4, 1).

 

 

 

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